Jacob Bell
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Pradeep Tyagi1, Vikas Tyagi1, Naoki Yoshimura2, Michael Chancellor1
1 Department of Urology, William Beaumont Hospital, MI 48073, USA
2 Department of Urology, University of Pittsburgh, PA 15213, USA
Date of Web Publication 23-Mar-2010
Correspondence Address:
Pradeep Tyagi
Department of Urology, William Beaumont Hospital, MI 48073
USA
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DOI: 10.4103/0970-1591.60440
PMID: 20535281
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Abstract
Cannabinoids, the active components of Cannabis sativa (marijuana), and their derivatives produce a wide spectrum of central and peripheral effects, some of which may have clinical applications. The discovery of specific cannabinoid receptors and a family of endogenous ligands of those receptors has attracted much attention to the general cannabinoid pharmacology. In recent years, studies on the functional role of cannabinoid receptors in bladder have been motivated by the therapeutic effects of cannabinoids on voiding dysfunction in multiple sclerosis patients. In this review, we shall summarize the literature on the expression of cannabinoid receptors in urinary bladder and the peripheral influence of locally and systemically administered cannabinoids in the bladder. The ongoing search for cannabinoid-based therapeutic strategies devoid of psychotropic effects can be complemented with local delivery into bladder by the intravesical route. A greater understanding of the role of the peripheral CB 1 and CB 2 receptor system in lower urinary tract is necessary to allow the development of new treatment for pelvic disorders.
Keywords: Bladder, cannabinoids, irritation, protein-coupled receptor, receptor expression
Source: Functional role of cannabinoid receptors in urinary bladder
1 Department of Urology, William Beaumont Hospital, MI 48073, USA
2 Department of Urology, University of Pittsburgh, PA 15213, USA
Date of Web Publication 23-Mar-2010
Correspondence Address:
Pradeep Tyagi
Department of Urology, William Beaumont Hospital, MI 48073
USA
Login to access the Email id
DOI: 10.4103/0970-1591.60440
PMID: 20535281
Get Permissions
Abstract
Cannabinoids, the active components of Cannabis sativa (marijuana), and their derivatives produce a wide spectrum of central and peripheral effects, some of which may have clinical applications. The discovery of specific cannabinoid receptors and a family of endogenous ligands of those receptors has attracted much attention to the general cannabinoid pharmacology. In recent years, studies on the functional role of cannabinoid receptors in bladder have been motivated by the therapeutic effects of cannabinoids on voiding dysfunction in multiple sclerosis patients. In this review, we shall summarize the literature on the expression of cannabinoid receptors in urinary bladder and the peripheral influence of locally and systemically administered cannabinoids in the bladder. The ongoing search for cannabinoid-based therapeutic strategies devoid of psychotropic effects can be complemented with local delivery into bladder by the intravesical route. A greater understanding of the role of the peripheral CB 1 and CB 2 receptor system in lower urinary tract is necessary to allow the development of new treatment for pelvic disorders.
Keywords: Bladder, cannabinoids, irritation, protein-coupled receptor, receptor expression
Source: Functional role of cannabinoid receptors in urinary bladder
