Jacob Bell
New Member
Author(s) Cooler P, Gregg JM
Journal, Volume, Issue Southern Medical Journal 1977;70(8):951-954
Major outcome(s) reduction in intraocular pressure
Indication Glaucoma
Medication Delta-9-THC
Dose(s) 1.5-3.0 mg THC
Duration (days) 1
Participants 10 healthy subjects
Design Controlled study
Abstract
As early as 1971, it was noted that smoking marijuana lowered intraocular pressure. In this study one of the active components of marijuana, delta-9-tetrahydrocannabinol, was given intravenously to ten subjects with normal intraocular pressures. Two strengths were used--0.022 mg/kg of body weight and 0.044 mg/kg of body weight. Intraocular pressure was found to decrease as much as 51% of baseline normal with an average decrease of 37%. Heart rate increased in a range of 22% and 65% of the resting pulse. Respiratory rate was not affected. No analgesic properties were demonstrated by either cutaneous or periosteal stimulation. Anxiety levels were increased by delta-9-tetrahydrocannabinol over placebo and diazepam (Valium). The mechanism of action is still uncertain but it is believed by some workers to be similar to that of a beta-adrenergic stimulator.
Source: Effect Of Delta-9-Tetrahydrocannabinol On Intraocular Pressure In Humans
Journal, Volume, Issue Southern Medical Journal 1977;70(8):951-954
Major outcome(s) reduction in intraocular pressure
Indication Glaucoma
Medication Delta-9-THC
Dose(s) 1.5-3.0 mg THC
Duration (days) 1
Participants 10 healthy subjects
Design Controlled study
Abstract
As early as 1971, it was noted that smoking marijuana lowered intraocular pressure. In this study one of the active components of marijuana, delta-9-tetrahydrocannabinol, was given intravenously to ten subjects with normal intraocular pressures. Two strengths were used--0.022 mg/kg of body weight and 0.044 mg/kg of body weight. Intraocular pressure was found to decrease as much as 51% of baseline normal with an average decrease of 37%. Heart rate increased in a range of 22% and 65% of the resting pulse. Respiratory rate was not affected. No analgesic properties were demonstrated by either cutaneous or periosteal stimulation. Anxiety levels were increased by delta-9-tetrahydrocannabinol over placebo and diazepam (Valium). The mechanism of action is still uncertain but it is believed by some workers to be similar to that of a beta-adrenergic stimulator.
Source: Effect Of Delta-9-Tetrahydrocannabinol On Intraocular Pressure In Humans
